abstract：OBJECTIVE:The use of thyrotropin (TSH) in the initial assessment of thyroid nodules is inefficient and leads to unnecessary assessment costs. We compared the total costs of thyroid nodule assessment with or without the use of TSH in the initial assessment. METHODS:A total of 1808 patients with thyroid nodules received...

journal_title：Clinical endocrinology

authors： Cai H,Qiao Y,Xi H,Luo Q,Yuan X,Yang Y,Lv Z

更新日期：2017-02-01 00:00:00

abstract：OBJECTIVE:Postablation whole-body scintigraphy, which is performed 5-7 days after administration of ablation activity of radioactive iodine-131 (131 I) in patients with thyroid cancer, is considered a routine procedure for remnant ablation and a useful tool for disease staging. However, the relationship of pre-ablation...

journal_title：Clinical endocrinology

authors： Liu B,Chen Y,Jiang L,He Y,Huang R,Kuang A

更新日期：2017-01-01 00:00:00

abstract：OBJECTIVE:Uncontrolled hypothyroidism has been associated with an increased risk of adverse pregnancy outcomes. We aimed to assess the effectiveness of increasing levothyroxine (LT4) dose on reducing the risk of adverse outcomes for pregnant women with TSH level greater than the recommended 1st trimester limit. DESIGN...

journal_title：Clinical endocrinology

authors： Maraka S,Singh Ospina NM,O'Keeffe DT,Rodriguez-Gutierrez R,Espinosa De Ycaza AE,Wi CI,Juhn YJ,Coddington CC 3rd,Montori VM

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND & OBJECTIVES:Postnatal depression correlates with postpartum weight retention, and dysregulated cortisol metabolism is evident in depressed individuals. Cortisol metabolism, BMI and metabolic phenotype are robustly associated, but the role of cortisol metabolism in postnatal mental health and weight loss has...

journal_title：Clinical endocrinology

authors： Rogers SL,Hughes BA,Tomlinson JW,Blissett J

更新日期：2016-12-01 00:00:00

abstract：OBJECTIVE:The prevalence of clinically silent corticotroph macroadenomas is unknown. Our aim was to determine the prevalence of clinically silent corticotroph macroadenomas among all pituitary macroadenomas. DESIGN:Patients scheduled to have transsphenoidal surgery for any sellar mass were prospectively evaluated clin...

journal_title：Clinical endocrinology

authors： Guttenberg KB,Mayson SE,Sawan C,Kharlip J,Lee JY,Martinez-Lage M,Loevner LA,Ewanichak J,Grady MS,Snyder PJ

更新日期：2016-12-01 00:00:00

abstract：OBJECTIVE:Thyroid dysfunction and obesity during pregnancy have been associated with negative neonatal and obstetric outcomes. Thyroid hormone reference ranges have not been established for the pregnant Hispanic population. This study defines thyroid hormone reference ranges during early pregnancy in Chilean women and ...

journal_title：Clinical endocrinology

authors： Mosso L,Martínez A,Rojas MP,Latorre G,Margozzini P,Lyng T,Carvajal J,Campusano C,Arteaga E,Boucai L

更新日期：2016-12-01 00:00:00

abstract：CONTEXT AND OBJECTIVE:Nonfunctioning pituitary adenomas (NFPAs) are the most common subtype of pituitary tumour. Hypopituitarism is observed in NFPAs due to tumour- or treatment-related factors and may increase mortality risk. Here, we analysed the associations of hypopituitarism, hormone replacement and mortality in a...

journal_title：Clinical endocrinology

authors： O'Reilly MW,Reulen RC,Gupta S,Thompson CA,Dineen R,Goulden EL,Bugg G,Pearce H,Toogood AA,Gittoes NJ,Mitchell R,Thompson CJ,Ayuk J

更新日期：2016-11-01 00:00:00

abstract：CONTEXT:The inconclusive evidence regarding long-term safety of recombinant human growth hormone (rhGH) therapy underlines the need for long-term large-scale cohorts. OBJECTIVE:To assess long-term mortality and cancer incidence among patients treated with rhGH during childhood in Israel. DESIGN:A population-based coh...

journal_title：Clinical endocrinology

authors： Libruder C,Blumenfeld O,Dichtiar R,Laron Z,Zadik Z,Shohat T,Afek A

更新日期：2016-11-01 00:00:00

abstract：INTRODUCTION:Growth hormone deficiency is considered the most important factor determining skeletal fragility in hypopituitary patients. Osteoblasts and chondrocytes express growth hormone (GH) receptor. Two GH receptor isoforms (GHRi) have been identified: they differ for the presence/absence of a protein fragment enc...

journal_title：Clinical endocrinology

authors： Mormando M,Chiloiro S,Bianchi A,Giampietro A,Angelini F,Tartaglione L,Nasto L,Milardi D,Formenti AM,Giustina A,De Marinis L

更新日期：2016-11-01 00:00:00

abstract：OBJECTIVE:The prevalence of autoimmune polyendocrine syndrome type 1 (APS1) among isolated hypoparathyroidism (HP) or primary adrenal insufficiency (PAI) is not well established. We studied the frequency of APS1 in patients with HP or PAI by measuring interferon-α (IFN-α) antibody levels, a highly sensitive and specifi...

journal_title：Clinical endocrinology

authors： Sahoo SK,Zaidi G,Srivastava R,Sarangi AN,Bharti N,Eriksson D,Bensing S,Kämpe O,Aggarwal A,Aggarwal R,Bhatia E

更新日期：2016-10-01 00:00:00

abstract：CONTEXT:Anaerobic capacity is impaired in adults with GH deficiency (GHD), adversely affecting physical function and quality of life (QoL). OBJECTIVE:To investigate whether GH replacement improves anaerobic capacity, physical function and QoL in adults with GHD. DESIGN:One-month double-blind placebo-controlled crosso...

journal_title：Clinical endocrinology

authors： Chikani V,Cuneo RC,Hickman I,Ho KK

更新日期：2016-10-01 00:00:00

abstract：OBJECTIVE:Adrenal crises are potentially life-threatening complications in patients with adrenal insufficiency (AI). Our objective was to investigate the frequency of adrenal crises in different forms of AI. DESIGN/PATIENTS:The Statutory Health Insurance (SHI) database of the Techniker Krankenkasse - covering more tha...

journal_title：Clinical endocrinology

authors： Meyer G,Badenhoop K,Linder R

更新日期：2016-09-01 00:00:00

abstract：OBJECTIVE:The effects of thiazide medication in patients with primary hyperparathyroidism (PHPT) have so far not been elucidated. The aim of this study was to analyse the extent to which the administration of thiazides may influence biochemical parameters and therefore the diagnosis of PHPT in a large cohort of patient...

journal_title：Clinical endocrinology

authors： Riss P,Kammer M,Selberherr A,Bichler C,Kaderli R,Scheuba C,Niederle B

更新日期：2016-08-01 00:00:00

abstract：BACKGROUND:The prognostic value of the telomerase reverse transcriptase (TERT) promoter mutation, resulting in poor clinical outcomes of papillary thyroid carcinoma (PTC), has been generally confirmed. To data, there is no high-level evidence approving the association of TERT promoter mutation and aggressive clinical b...

journal_title：Clinical endocrinology

authors： Yin DT,Yu K,Lu RQ,Li X,Xu J,Lei M,Li H,Wang Y,Liu Z

更新日期：2016-08-01 00:00:00

abstract：AIM:A high level of matrix metalloproteinase 9 (MMP-9) is a predictor of poor wound healing in diabetic foot ulcers. In skin keratinocytes, site-specific DNA demethylation plays an important role in MMP-9 expression. Ten-eleven translocation enzyme 2 (TET2) protein, one member of TET family, could rely on α-ketoglutara...

journal_title：Clinical endocrinology

authors： Tan Q,Wang W,Yang C,Zhang J,Sun K,Luo HC,Mai LF,Lao Y,Yan L,Ren M

更新日期：2016-07-01 00:00:00

abstract：OBJECTIVE:The objective of this study was to evaluate symptoms of thyrotoxicosis, bone turnover, bone mineral density (BMD) and occult atrial fibrillation (AF) in women ≥65 years with mild endogenous subclinical hyperthyroidism (SCH). DESIGN:Cross-sectional and case-control study. PATIENTS:Signs and symptoms of thyro...

journal_title：Clinical endocrinology

authors： Rosario PW,Carvalho M,Calsolari MR

更新日期：2016-07-01 00:00:00

abstract：OBJECTIVE:Abdominal visceral (VAT) and subcutaneous (SAT) adipose tissues contribute to obesity, but may have different cardiometabolic risk profiles. We examined and compared the associations of abdominal VAT and SAT with metabolic risk factors in a large cohort of Chinese adults. METHODS:This study was based on cros...

journal_title：Clinical endocrinology

authors： Tang L,Zhang F,Tong N

更新日期：2016-07-01 00:00:00

abstract：OBJECTIVE:The risk of progression of subclinical hypothyroidism (SCH) to clinical dysfunction is one of the factors considered in the decision to treat this condition. This study evaluated the natural history of SCH in women with TSH ≤10 mIU/l. DESIGN:This is a prospective study. PATIENTS:Two hundred and fifty-two wo...

journal_title：Clinical endocrinology

authors： Rosário PW,Carvalho M,Calsolari MR

更新日期：2016-06-01 00:00:00

abstract：BACKGROUND:Low vitamin D has been associated with poor arterial compliance in observational studies. Arterial stiffness has prognostic value for cardiovascular disease risk. The aim of this systematic review was to clarify the literature surrounding the use of vitamin D to ameliorate arterial stiffness. METHODS:We con...

journal_title：Clinical endocrinology

authors： Rodríguez AJ,Scott D,Srikanth V,Ebeling P

更新日期：2016-05-01 00:00:00

abstract：BACKGROUND:Pregnancy and lactation comprise a critical window spanning all seasons during which maternal vitamin D status potentially may influence the long-term health of the newborn. Women typically receive calcium/vitamin D supplementation through antenatal vitamins, but there has been limited serial evaluation of m...

journal_title：Clinical endocrinology

authors： Kramer CK,Ye C,Swaminathan B,Hanley AJ,Connelly PW,Sermer M,Zinman B,Retnakaran R

更新日期：2016-05-01 00:00:00

abstract：BACKGROUND:Patients with idiopathic hypoparathyroidism (IH) require variable doses of calcium and 1-α-(OH)D. The reasons for such variability are not clear. As autoimmune mechanisms may play a role in IH, there is a possibility of coexistent coeliac disease with calcium/vitamin D malabsorption. OBJECTIVE:We assessed t...

journal_title：Clinical endocrinology

authors： Saha S,Saini S,Makharia GK,Datta Gupta S,Goswami R

更新日期：2016-04-01 00:00:00

abstract：BACKGROUND:Efficacy of the GH-receptor antagonist pegvisomant (PEG) has differed between preclinical and observational studies mainly due to dose adjustment and IGF-I normalization criteria. An escape phenomenon has also been described, but its definition and underlying causes have not been fully established. OBJECTIV...

journal_title：Clinical endocrinology

authors： Ramos-Leví AM,Bernabeu I,Álvarez-Escolá C,Aller J,Lucas T,de Miguel P,Rodríguez-Cañete L,Sampedro-Núñez MA,Halperin I,Puig-Domingo M,Marazuela M

更新日期：2016-04-01 00:00:00

abstract：OBJECTIVE:Precocious pubarche (PP) has been linked to higher prevalence of metabolic disturbances and polycystic ovary syndrome (PCOS). The aim of the study was to assess echocardiographic parameters in PP girls and to analyse their relationship with androgens and insulin resistance (IR). DESIGN:Case-control study. P...

journal_title：Clinical endocrinology

authors： Satler F,Vieira Rdo A,Firpo C,Spritzer PM

更新日期：2016-03-01 00:00:00

abstract：CONTEXT:Data on quantification and regulation of adipsin in human cerebrospinal fluid (CSF) are sparse, and the physiological role of adipsin as an adipokine crossing the blood-brain barrier (BBB) is uncertain. OBJECTIVES:This study quantified adipsin concentrations in paired serum and CSF samples of patients undergoi...

journal_title：Clinical endocrinology

authors： Schmid A,Hochberg A,Berghoff M,Schlegel J,Karrasch T,Kaps M,Schäffler A

更新日期：2016-02-01 00:00:00

abstract：BACKGROUND:Thyroid cancer incidence has been increasing worldwide. Some suggest greater ascertainment of indolent tumours is the only driver, but others suggest there has been a true increase. Increases in Australia appear to have been among the largest in the world, so we investigated incidence trends in the Australia...

journal_title：Clinical endocrinology

authors： Pandeya N,McLeod DS,Balasubramaniam K,Baade PD,Youl PH,Bain CJ,Allison R,Jordan SJ

更新日期：2016-02-01 00:00:00

abstract：OBJECTIVE:Fracture risk in type 2 diabetes mellitus with insulin resistance is increased, despite relatively preserved bone mineral density (BMD). In this study, we investigated the relationship between insulin resistance and composite indices of femoral neck strength in Koreans. DESIGN:A population-based, cross-secti...

journal_title：Clinical endocrinology

authors： Ahn SH,Kim H,Kim BJ,Lee SH,Koh JM

更新日期：2016-02-01 00:00:00

abstract：OBJECTIVE:Serum thyroglobulin (Tg) is a marker of residual differentiated thyroid cancer (DTC) after total thyroidectomy; however, circulating antithyroglobulin antibodies (TgAb) may interfere with the immunoassay for Tg. Ultrasensitive assays may have a more significant role in detecting circulating Tg in the context ...

journal_title：Clinical endocrinology

authors： McGrath RT,Preda VA,Clifton-Bligh P,Robinson B,Sywak M,Delbridge L,Ward P,Clifton-Bligh RJ,Learoyd DL

更新日期：2016-02-01 00:00:00

abstract：OBJECTIVE:The objective of this study was to determine the levels of thrombospondin-1 (TSP-1), transforming growth factor-β1 (TGF-β1) and nuclear factor kappaβ (NF-κβ) in polycystic ovarian syndrome (PCOS) patients with and without insulin resistance and after treatment with cyproterone acetate/ethinyloestradiol with o...

journal_title：Clinical endocrinology

authors： Liu M,Gao J,Zhang Y,Li P,Wang H,Ren X,Li C

更新日期：2015-12-01 00:00:00

abstract：CONTEXT:Hypoparathyroidism is characterized by hypocalcaemia, hyperphosphataemia, and low or inappropriately normal parathyroid hormone (PTH) levels. Idiopathic or genetic drivers are the predominant causes of hypoparathyroidism in paediatric-age patients. OBJECTIVE:This study investigated the aetiology and clinical c...

journal_title：Clinical endocrinology

authors： Kim JH,Shin YL,Yang S,Cheon CK,Cho JH,Lee BH,Kim GH,Lee JO,Seo EJ,Choi JH,Yoo HW

更新日期：2015-12-01 00:00:00

abstract：OBJECTIVE:To study the association between serum anti-Müllerian hormone (AMH) levels and follicular development and endocrine responses induced by increasing doses (5·2-12·1 μg/day) of a novel recombinant human FSH (rhFSH, FE 999049) in patients undergoing in vitro fertilization (IVF)/intracytoplasmic sperm injection (...

journal_title：Clinical endocrinology

authors： Bosch E,Nyboe Andersen A,Barri P,García-Velasco JA,de Sutter P,Fernández-Sánchez M,Visnova H,Klein BM,Mannaerts B,Arce JC

更新日期：2015-12-01 00:00:00

abstract：OBJECTIVE:Staging systems applied to medullary thyroid cancer (MTC) rely on initial clinical and pathological features and do not consider the response to treatment. To determine whether MTC staging can be improved by incorporating the first postoperative calcitonin measurement. PATIENTS AND MEASUREMENTS:Eighty-five p...

journal_title：Clinical endocrinology

authors： Yang JH,Lindsey SC,Camacho CP,Valente FO,Germano-Neto F,Machado AL,Mamone MC,Brodskyn F,Biscolla RP,Tuttle RM,Dias-da-Silva MR,Maciel RM

更新日期：2015-12-01 00:00:00

abstract：OBJECTIVES:Cytokines have an important role in orchestrating the pathophysiology in autoimmune thyroid disease. The aim of the current study was to analyse the expression of interleukin (IL)-14 and IL-16 in the thyroid tissue of patients with Graves' disease (GD), Hashimoto's thyroiditis (HT) or multinodular goitre (MN...

journal_title：Clinical endocrinology

authors： Kemp EH,Ajjan RA,Metcalfe RA,Watson PF,Weetman AP

更新日期：2015-11-01 00:00:00

abstract：CONTEXT:Vitamin D deficiency is widely prevalent throughout the world. Pregnant women, neonates and infants form most vulnerable groups for vitamin D deficiency. OBJECTIVE:(1) To find prevalence of vitamin D deficiency in pregnant women. (2) To evaluate the effect of supplementation with cholecalciferol in improving v...

journal_title：Clinical endocrinology

authors： Sablok A,Batra A,Thariani K,Batra A,Bharti R,Aggarwal AR,Kabi BC,Chellani H

更新日期：2015-10-01 00:00:00

abstract：BACKGROUND:Metadherin (MTDH) protein, also called astrocyte elevated gene-1 (AEG-1) is over expressed in a variety of malignant tumours, and is closely related to tumour invasion and the poor prognosis. OBJECTIVE:This study tries to explore the clinical pathological significance of MTDH expression in a large cohort of...

journal_title：Clinical endocrinology

authors： Li WF,Wang G,Zhao ZB,Liu CA

更新日期：2015-10-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to investigate the diagnostic performance of pre-operative staging ultrasound (US) according to body mass index (BMI) in patients with papillary thyroid carcinoma (PTC) PATIENTS AND METHODS: This retrospective study included 625 patients with PTC who underwent pre-operative staging U...

journal_title：Clinical endocrinology

authors： Choi JS,Lee HS,Kim EK,Moon HJ,Kwak JY

更新日期：2015-10-01 00:00:00

abstract：OBJECTIVE:PCOS is associated with obesity and insulin resistance. Efforts have focused on whether an abnormal energy homeostasis contributes to the development of obesity in these patients. There are conflicting results in the literature regarding whether women with PCOS have an altered basal metabolic rate (BMR), ther...

journal_title：Clinical endocrinology

authors： Churchill SJ,Wang ET,Bhasin G,Alexander C,Bresee C,Pall M,Azziz R,Mathur R,Pisarska MD

更新日期：2015-09-01 00:00:00

abstract：OBJECTIVE:To determine whether maternal vitamin D supplementation, in the vitamin D deficient mother, prevents neonatal vitamin D deficiency. DESIGN:Open-label randomized controlled trial. SETTING:Metropolitan Melbourne, Australia, tertiary hospital routine antenatal outpatient clinic. PARTICIPANTS:Seventy-eight wom...

journal_title：Clinical endocrinology

authors： Rodda CP,Benson JE,Vincent AJ,Whitehead CL,Polykov A,Vollenhoven B

更新日期：2015-09-01 00:00:00

abstract：OBJECTIVE:Cadmium (Cd) has been shown to impair pubertal development in experimental animals. However, no data are available for male adolescents with increased urinary cadmium levels. DESIGN:The aim of this cross-sectional study was to evaluate pubertal onset and pituitary-gonadal axis hormones in male adolescents wi...

journal_title：Clinical endocrinology

authors： Interdonato M,Pizzino G,Bitto A,Galfo F,Irrera N,Mecchio A,Pallio G,Ramistella V,De Luca F,Santamaria A,Minutoli L,Marini H,Squadrito F,Altavilla D

更新日期：2015-09-01 00:00:00

abstract：OBJECTIVES:Mutations in the dual oxidase 2 gene (DUOX2) is the most common genetic cause of congenital hypothyroidism (CH) in Japan. All previously described DUOX2 mutation-carrying families have followed autosomal recessive inheritance. We report a nonconsanguineous Japanese family harbouring biallelic DUOX2 mutations...

journal_title：Clinical endocrinology

authors： Abe K,Narumi S,Suwanai AS,Hamajima T,Hasegawa T

更新日期：2015-09-01 00:00:00

abstract：OBJECTIVE:We investigated correlations between age-related changes in circulating metabolites and arterial stiffness in impaired fasting glucose (IFG). DESIGN, SUBJECTS, MEASUREMENT:This prospective cohort study included 602 healthy, normal fasting glucose (NFG) subjects (30-65 years old) who underwent triennial medic...

journal_title：Clinical endocrinology

authors： Jung S,Kim M,Lee YJ,Lee SH,Lee JH

更新日期：2015-08-01 00:00:00